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在日本患有努南综合征的患者中,随着年龄的增长,心电图变化
Yasuhiro Ichikawa1,2, Hiroyuki Kuroda1, Takeshi Ikegawa1
1Department of Cardiology, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama 232-8555, Kanagawa, Japan.
诺南综合征的心电图变化随年龄而异,婴儿显示出更多的右轴偏差和小R波. 这些发现有助于在幼儿中诊断努南综合征.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 儿科 儿科 儿科
背景情况:
- 努南综合征是一种遗传性疾病,具有各种临床表现.
- 有限的数据存在于与年龄相关的心电图 (ECG) 变化在诺南综合征患者.
研究的目的:
- 为了评估与Noonan综合征患者的年龄相关的心电图变化.
- 确定特定的心电图模式,可以帮助诊断婴儿和幼儿的努南综合征.
主要方法:
- 一项单中心研究分析了来自112名诺南综合征患者的256个心电图.
- 患者被分为四个年龄组:1个月-1年,1-6岁,6-12岁和>12岁.
- 评估了标准的心电图参数,包括QRS轴,QRS复合宽度和波形态.
主要成果:
- 常见的努南综合征心电图特征包括左轴偏差,异常的Q波,宽的QRS复合体和前线中的小R波.
- 在所有年龄组中,QRS轴异常普遍存在.
- 与年龄较大的群体相比,最年轻的群体 (1个月-1岁儿童中56.5%) 的右轴偏差 (RAD) 显着更高.
- 在最年轻的患者中,1个月至1岁的患者中,小R波在前线中也更频繁 (32.6%).
- 在1个月至2岁的患者中,在53例中18例中观察到T阳性V1,与较高的肺狭窄率和心脏干预相关.
结论:
- 在努南综合征中存在特定年龄的心电图发现,特别是在婴儿和幼儿中.
- 在最年轻的年龄组中,RAD和小R波的患病率增加值得注意.
- 电脑心电图的发现,如QRS轴异常,V6中的小R,T阳性V1可能有助于在儿科患者中诊断努南综合征.
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