![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
致癌诱导的临床前癌症模型的相关性
Raj N Sewduth1, Konstantina Georgelou2
1VIB KU Leuven Center for Cancer Biology, 49 Herestraat, 3000 Leuven, Belgium.
Journal of xenobiotics
|January 22, 2024
概括
化学诱导的临床前癌症模型通过模仿瘤复杂性来帮助人类癌症研究. 然而,由于物种差异和可变的化学效应,仔细验证和解释至关重要.
科学领域:
- 在瘤学瘤学.
- 毒理学 毒理学 毒理学
- 遗传学 遗传学 是一个
背景情况:
- 化学致癌物通过改变DNA,基因和表观遗传特征来诱导癌症.
- 临床前癌症模型对于研究致癌物诱导的人类癌症,复制瘤多样性和宿主相互作用是有价值的.
- 现有的模型面临局限性,包括化学疗效/毒性和瘤遗传/表型变异的物种间差异.
研究的目的:
- 提供化学诱导癌症模型的全面概述.
- 讨论这些模型的特点,优点和缺点.
- 确定改善致癌物诱导癌症模型的挑战和未来方向.
主要方法:
- 关于化学诱导癌症模型的科学文献的综述.
- 分析遗传和表观遗传变化,瘤微环境,血管新生,入侵,转移和免疫反应.
- 评估模型的局限性,包括化学变异性和宿主因素.
主要成果:
- 化学诱导模型表现出遗传和表观遗传变化,影响瘤环境,血管新生,入侵,转移和免疫反应.
- 模型的有效性受到物种特异性的化学反应,正常组织变化 (氧化应激,炎症) 和暴露变量 (剂量,途径,持续时间) 的影响.
- 瘤的行为和治疗反应可以通过对正常细胞和组织的化学作用而改变.
结论:
- 化学诱导的癌症模型提供了洞察力,但需要仔细选择,验证和标准化.
- 这些模型的结果需要谨慎地解释和与其他研究方法进行比较.
- 解决模型的局限性是推动癌症研究和开发新治疗策略的关键.
更多相关视频
09:29Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
13.8K
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
相关概念视频
02:43Mouse Models of Cancer Study
5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K
01:25Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K