人类细胞巨乳病毒是情绪障碍的潜在危险因素吗? 一个系统的审查和元分析
Zahra Yousefian1, Seyedeh Masoumeh Seyedhosseini Tamijani1, Hamed Ghazvini1
1Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Indian journal of psychiatry
|January 22, 2024
概括
细胞巨乳病毒 (CMV) 感染可能与情绪障碍有关. 这次元分析发现,与对照人群相比,情绪障碍患者的CMV血清阳性较高.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 情绪障碍对全球健康构成重大负担.
- 细胞巨乳病毒 (CMV) 是一种持久性病毒,可以在免疫抑制期间重新激活.
- 长期存在的CMV和潜在的神经效应需要对其在心理健康中的作用进行调查.
研究的目的:
- 为了确定心情障碍的个体中人类细胞巨乳病毒 (CMV) 的血清流行率.
- 检查CMV感染与情绪障碍发病率之间的关联.
主要方法:
- 在主要的科学数据库 (2000-2023) 中进行了系统的文献搜索.
- 符合条件的研究经过了质量评估和纳入/排除标准选.
- 对八篇选定的文章进行了元分析,以综合发现.
主要成果:
- 在情绪障碍患者中,CMV的整体血清阳性率为51.6% (95% CI; 42.8-60.4).
- 在情绪障碍患者和对照组 (13.27% vs 10.45%) 之间观察到CMV血清阳性的统计学上显著差异.
- 使用埃格尔测试的出版偏差分析表明,子组内没有显著的偏差.
结论:
- 冠状病毒感染可能与情绪障碍的增加风险或存在有关.
- 这些发现突出了心情障碍和没有心情障碍的个体之间的CMV血清阳性显著差异.
- 需要进一步的研究来阐明将CMV与情绪障碍联系在一起的因果机制.
更多相关视频
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.5K
05:28A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
Published on: May 15, 2019
22.2K
相关概念视频
Human Genetics
572
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
572
Depressive Disorders: Etiology
102
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
102
Bipolar Disorder
67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Depression: Overview
247
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
247
Stress and Mental Health
157
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
157
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31
