关于精神分裂症神经软标志和认知的研究
Yashika L Nathani1, Abhijeet Faye2, Vivek Kirpekar3
1Psychiatry, Gujarat Medical Education and Research Society Medical College, Vadodara, IND.
Cureus
|January 22, 2024
概括
神经软体征 (NSS) 和认知障碍在精神分裂症中很常见. 这项研究发现NSS,特别是运动协调缺陷和患者的认知功能障碍之间存在显著的关联,这突显了它们在精神分裂症评估中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 神经软征兆 (NSS) 是微妙的神经异常,不特定于任何大脑区域.
- 在被诊断为精神分裂症的人群中,经常观察到NSS和认知功能障碍.
- 评估NSS及其与认知障碍的关系对于理解精神分裂症至关重要.
研究的目的:
- 评估精神分裂症患者中NSS的患病率.
- 在这个人群中确定NSS和认知障碍之间的关联.
- 探索NSS,认知缺陷和症状严重程度之间的关系.
主要方法:
- 100名精神分裂症患者使用海德堡级别对NSS进行了评估.
- 用蒙特利尔认知评估 (MoCA) 尺度评估认知功能.
- 精神分裂症症状严重程度用正负综合征量表 (PANSS) 和简短精神病学评分量表 (BPRS) 进行测量.
主要成果:
- 在68%的患者中发现了NSS,其中运动协调缺陷是最常见的.
- 认知障碍 (MoCA 分数<26) 在73%的患者中存在.
- 在NSS和认知障碍之间发现了统计学上显著的相关性,较高的NSS得分与负面症状和较低的MoCA得分有关.
结论:
- 在精神分裂症的认知缺陷,负面症状和NSS之间存在显著的关联.
- 精神分裂症和认知功能障碍是精神分裂症症状领域的组成部分.
- 建议对NSS进行评估,特别是运动协调和认知问题,因为它们与负面症状和疾病严重程度有关.
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