对表达HER2的结直肠癌的治疗选择:最新情况和最近的批准
Binbin Zheng-Lin1, Tanios S Bekaii-Saab2
1Division of Hematology and Oncology, Mayo Clinic, Phoenix, AZ, USA.
Therapeutic advances in medical oncology
|January 22, 2024
概括
人类表皮生长因子受体2 (HER2) 放大发生在3 - 5%的结直肠癌中. 本综述总结了HER2扩散性结直肠癌的抗HER2药物与HER2放大.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因之一.
- 人体表皮生长因子受体2 (HER2) 放大发现在CRC瘤的3-5%中,与预后不佳和内转移的增加相关.
- 转移性RAS野生型CRC与HER2放大是一种独特的临床实体.
研究的目的:
- 审查目前转移性结直肠癌的抗HER2疗法的现状.
- 总结现有和新兴的HER2向剂的疗效和安全数据.
- 为临床医生提供有关管理HER2增强转移性CRC的基本信息.
主要方法:
- 临床试验和相关文献的系统审查.
- 对针对HER2的单克隆抗体,氨酸激酶抑制剂和抗体-药物结合物的数据分析.
- 综合有关治疗机制,临床结果和安全性资料的信息.
主要成果:
- 几种抗HER2药物在耐火性转移性RAS野生型CRC中表现出临床活性.
- 抗体-药物联体是一种有前途的治疗类.
- 目前正在进行的试验继续扩大对抗HER2阳性CRC的武器库.
结论:
- 抗HER2疗法为转移性结直肠癌患者的一个子集提供了可行的治疗选择.
- 对HER2向剂的熟悉对于有效的临床管理至关重要.
- 进一步的研究和临床试验对于优化治疗策略至关重要.
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