智能手机传感器用于评估癌症患者的COVID-19恐惧:一项前性研究
Gabrielė Kasputytė1, Gabrielė Jenciūtė1, Nerijus Šakinis1
1Faculty of Informatics, Vytautas Magnus University, Kaunas, Lithuania.
Frontiers in public health
|January 22, 2024
概括
通过智能手机传感器跟踪的癌症患者的行为,揭示了COVID-19恐惧和流动性减少之间的联系. 接种疫苗状态也影响了运动模式,未接种疫苗的患者表现出较少的活动.
科学领域:
- 在瘤学瘤学.
- 数字健康数字健康
- 行为科学 行为科学
背景情况:
- COVID-19 疫情对癌症患者的生活和行为产生了重大影响.
- 了解COVID-19的恐惧和疫苗接种情况如何影响癌症患者的日常活动对于支持性护理至关重要.
研究的目的:
- 分析通过智能手机传感器数据 (数字表型) 测量的癌症患者行为与他们对COVID-19的感知恐惧之间的关联.
- 研究COVID-19疫苗接种情况与癌症患者的行为变化之间的关系.
主要方法:
- 202名癌症患者完成了COVID-19恐惧问卷,并记录了他们的疫苗接种状态.
- 智能手机应用程序被动收集了至少两周的107名患者的高分辨率行为数据.
- 统计分析,包括奇平方测试,曼-惠特尼,克鲁斯卡尔-瓦利斯和局部多项式回归,用于比较组和数据轨迹.
主要成果:
- 对COVID-19的更高恐惧与在家度过的时间增加,旅行距离缩短和参观感兴趣的地方 (POI) 较少相关.
- 与部分接种疫苗的患者相比,完全接种疫苗或未接种疫苗的患者报告了更大的COVID-19恐惧.
- 接种疫苗的患者 (完全或部分) 比未接种疫苗的患者多访问POI;部分接种疫苗的患者在一周后显示POI访问的持续增加.
结论:
- 癌症患者的行为,包括移动性和在家度过的时间,仍然受到COVID-19大流行的影响.
- 感知到COVID-19的恐惧是与癌症患者减少体力活动和社会参与相关的重要因素.
- COVID-19 疫苗接种状态影响行为模式,未接种疫苗的患者与接种疫苗的患者相比,总体上表现出较少的运动和较少的地点访问.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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