在患有儿科固体瘤患者的口腔微生物组特征
Xichun Cui1, Xiaoran Du1, Xu Cui1
1Pediatric Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in microbiology
|January 22, 2024
概括
儿科固体瘤 (PST) 患者的口腔微生物组显示出减少的多样性. 特定的细菌属和基因功能发生了改变,这表明PST的潜在的非侵入性诊断生物标志物.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 儿科 儿科 儿科
背景情况:
- 儿科固体瘤 (PST) 是儿童的重大健康问题.
- 虽然口腔微生物组与成人癌症的联系是已知的,但由于其独特的特征,其在儿科固体瘤中的作用需要特别调查.
- 了解儿科癌症口腔微生物群对于识别独特的疾病关联至关重要.
研究的目的:
- 描述患有固体瘤的儿童口腔微生物组的组成.
- 确定儿科固体瘤患者和健康对照者之间的口腔微生物群多样性和丰富性的差异.
- 探索潜在的微生物生物标志物用于儿科固体瘤诊断.
主要方法:
- 从23名儿科固体瘤患者和20名健康对照组收集了43个唾液样本.
- 在选样本上进行微生物MiSeq测序.
- 分析了口腔微生物组属性,包括细菌属和基因功能.
主要成果:
- 在小儿固体瘤患者中观察到口腔微生物群多样性的显著下降.
- 与对照组相比,在儿科固体瘤患者中鉴定出18种富含的细菌属 (例如,Veillonellaceae,Firmicutes未分类).
- 在小儿固体瘤患者中发现了16个基因功能 (例如,氨基酸代谢) 的显著丰富,而29个基因功能在健康对照组中占主导地位.
结论:
- 这项研究提供了儿童固体瘤患者口腔微生物群的第一个特征.
- 口腔微生物组的变化可以作为儿科固体瘤的潜在的非侵入性诊断生物标志物.
- 对这些微生物特征的进一步研究可能会导致新的诊断策略.
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