阿尔茨海默氏病和微生物:非编码RNA交叉交谈
Hanieh Mohammadi-Pilehdarboni1,2, Mohammad Shenagari2,3, Farahnaz Joukar2
1Faculty of Medicine and Dentistry and the School of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.
Frontiers in cellular neuroscience
|January 22, 2024
概括
微生物组和病毒感染通过神经炎症导致阿尔茨海默氏症 (AD) 病原发生. 非编码RNAs (ncRNAs) 是神经退行性疾病的关键调节者,提供潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 阿尔茨海默氏症 (AD) 是一种复杂的神经退行性疾病,具有多因素的原因,包括遗传,环境和人口因素.
- 新出现的证据突出显示了微生物组和病毒感染在阿尔茨海默病发病过程中的重要作用,主要是通过涉及神经炎症的机制.
- 非编码RNAs (ncRNAs) 越来越多地被认为是它们在调节神经退行性疾病相关途径中的关键作用.
研究的目的:
- 审查当前对微生物组和病毒病原体对阿尔茨海默病 (AD) 的贡献的理解.
- 阐明神经炎症作为微生物诱导的AD病变发生的关键媒介的作用.
- 探索非编码RNAs (ncRNAs) 在神经退行性疾病中的参与和治疗潜力,特别是AD.
主要方法:
- 关于阿尔茨海默病,微生物组,病毒感染,神经炎症和非编码RNA (ncRNAs) 的科学研究的文献综述.
- 对将环境因素,特别是微生物,与神经退行性疾病途径联系起来的研究进行分析.
- 关于ncRNAs在神经炎症和神经退行症中的调节功能发现的综合.
主要成果:
- 微生物感染,包括肠道细菌和病毒,与阿尔茨海默病 (AD) 的发展有关.
- 由微生物刺激引发的神经炎症,在AD中观察到的神经病理变化中起着关键作用.
- 非编码RNAs (ncRNAs) 被确定为神经退行相关途径的显著调节器,呈现潜在的治疗途径.
结论:
- 环境因素,特别是微生物组和病毒感染,是阿尔茨海默氏症 (AD) 病原发生的关键因素.
- 了解微生物剂,神经炎症和ncRNAs之间的相互作用对于开发有效的AD疗法至关重要.
- 针对ncRNAs提供了一个有前途的战略,用于未来的治疗干预在神经退行性疾病,如AD.
相关概念视频
Types of RNA
63.7K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
63.7K
Alzheimer's Disease: Overview
490
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
490
MicroRNAs
21.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.3K
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
RNA Editing
9.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
siRNA - Small Interfering RNAs
16.8K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.8K


