通过通过2D分散光谱仪分析WGM微激光发射来检测局部折射率和吸收变化的高灵敏度检测
Xuewen Zhou1, Malte C Gather2, Giuliano Scarcelli1
1Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
概括
一个新的二维分散光谱仪通过实现高光谱分辨率显著改善了生物传感. 这一进步克服了检测微激光辐射微妙变化的局限性,用于增强的折射率和吸收测量.
科学领域:
- 光学和光子学 在光学和光子学.
- 频谱学是一种光谱学.
- 生物传感技术的技术
背景情况:
- 微激光器为生物传感应用提供高灵敏度.
- 目前的检测系统,通常是格子谱仪,由于光谱分辨率差,限制了灵敏度.
- 需要先进的检测系统,以充分利用微激光器的灵敏度.
研究的目的:
- 开发和描述一个高分辨率的二维 (2D) 分散光谱仪.
- 在基于微激光的传感中克服传统检测系统的光谱分辨率限制.
- 为了能够精确测量微激光光谱变化和线宽变化.
主要方法:
- 使用虚拟成像相位阵列标准和衍射格的2D分散光谱仪的构建和表征.
- 从商业光微球作为微激光器使用的排放的分析.
- 在液体介质中测量折射率和吸收变化.
主要成果:
- 为了分析微激光发射,实现了比0.300 pm更好的光谱分辨率.
- 证明了高精度测量激光峰值发射波长中的光谱变化.
- 确定了1.37 × 10-5 RIU的检测极限,用于折射率变化和<0.02 cm-1的吸收变化.
结论:
- 开发的2D分散光谱仪显著提高了基于微激光的生物传感器的精度.
- 这项技术克服了检测系统所施加的以前的灵敏度限制.
- 该光谱仪能够非常精确地测量折射率和吸收率,扩大微激光在敏感检测中的应用.
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