预测参与部位放射治疗后的长期存活率,以预测寡甲基转移的发生
Johnny Kao1,2, Patricia Eckardt3, Jennifer Mceachron4
1Department of Radiation Oncology, Good Samaritan University Hospital, West Islip, NY 11795, USA.
Oncology letters
|January 22, 2024
概括
激进放射治疗为患有小转移症的患者提供长期生存,定义为五个或更少的转移性病变. 关键的生存因素包括年龄,表现状况,原发性癌症类型和白蛋白水平.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 癌症转移 癌症转移
背景情况:
- 远程转移是癌症死亡的主要原因,全身治疗往往不足以治愈.
- 患有寡聚转移的患者可能会通过参与部位放射治疗实现长期存活,但预后因素需要进一步定义.
研究的目的:
- 为了评估激进放射治疗在患有寡聚转移的患者中的疗效.
- 确定影响这一患者群体整体存活时间的预后因素.
主要方法:
- 在2014年至2021年期间,对130名患有固体瘤寡度转移的成年患者进行了回顾性分析.
- 定义为≤5可治疗的脑外或脑内病变,包括原发性瘤/区域结节.
- 激光疗法 (立体或强度调节) 用于所有已知的疾病部位.
主要成果:
- 平均整体存活时间为37.9个月,四年整体存活率为41.1%.
- 无进展生存时间的中位数为12.3个月,无进展生存时间为4年22.6%.
- 总生存率最强的预测因素包括年龄,ECOG表现状态,原发性癌症 (前列腺,乳腺,脏) 和辐射前血清白蛋白.
结论:
- 对寡头转移的激进治疗可以导致长期的整体存活.
- 年龄,表现状况,原发性瘤类型和血清白蛋白是小细胞瘤转移性癌症患者生存的显著预后因素.
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