重新检查两种节律发生器,用于灯的呼吸
Kianoush Missaghi1, Jean-Patrick Le Gal1, Julien Mercier1,2
1Département de Neurosciences, Université de Montréal, Montréal, QC, Canada.
Frontiers in neuroanatomy
|January 22, 2024
概括
这项研究确切地指出了鱼呼吸节奏的脑干位置. 快节奏发生器被证实在横向后脑中,而缓慢节奏发生器在尾部后脑的侧面体中.
科学领域:
- 神经科学是一个神经科学.
- 比较生理学比较生理学
- 呼吸系统控制 呼吸系统控制
背景情况:
- 兰普里呼吸表现出明显的快速和缓慢的节奏.
- 之前的研究提出了快速呼吸节律发生器的相互矛盾的位置.
- 缓慢的呼吸节奏的神经回路仍然不太了解.
研究的目的:
- 在解剖学和生理学上描述大脑干的区域,产生快速和缓慢的呼吸节奏.
- 解决关于快节奏发生器位置的相互矛盾数据.
- 为了识别和定位参与缓慢呼吸节律生成的神经元.
主要方法:
- 解剖病变研究和生理记录被用来重新检查快节奏发生器的位置.
- 单边注射解剖学标记剂与刺激实验相结合,绘制缓慢节奏发生器的地图.
- 电气和化学刺激,以及物质P注射,用于评估确定的神经元群体的功能.
主要成果:
- 快速呼吸节律发生器被证实位于三胞胎运动核的面向侧面.
- 尾部后脑侧层层中的分布式神经元群被确定为缓慢节奏发生器.
- 这些尾部神经元的刺激启动了缓慢的节奏爆发,而无活化则取消了它;物质P加速了缓慢的节奏.
结论:
- 的快速呼吸节奏发生器主要位于三角运动核的面向侧面.
- 缓慢的呼吸节律发生器分布在尾部后脑的侧面体内.
- 这项研究阐明了在鱼中产生双重呼吸节奏的基础的神经基质.
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