专家一致认为,系统性皮质糖类药物可以用于治疗与乙氨基酸相关的疾病
Victoria Del Pozo1, Irina Bobolea2, Manuel J Rial3,4
1Immunology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain.
Frontiers in immunology
|January 22, 2024
概括
系统性皮质糖类药物 (SGC) 治疗与乙氨基酸相关的疾病,但针对白蛋白-5的生物药物提供了一种减少SGC使用和相关不良影响的方法. 早期的生物治疗可以预防长期的SGC并发症.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
背景情况:
- 与乙氨基基酸相关的疾病包括各种各样的疾病,严重程度各不相同.
- 系统性皮质糖类药物 (SGC) 是对系统性和局部性酸性疾病的首要治疗方法.
- 针对白蛋白-5的新生物疗法提供了减少SGC依赖性和相关不良影响 (AE) 的替代方案.
研究的目的:
- 审查当前证据和专家临床经验SGC在特定的eosinophilic疾病的使用.
- 建立关于SGC剂量,逐渐减少以及生物制剂作为SGC节约剂的作用的共识.
- 评估早期生物干预的潜力,以减轻与SGC相关的AE.
主要方法:
- 专家小组对现有证据的审查.
- 名义小组技术,以实现共识.
- 专注于带有多膜炎 (EGPA) 的异酸性粒状瘤,超异酸性综合征 (HES),带有鼻多 (CRSwNP) 的慢性犀牛鼻炎和带有异酸性表因型 (SA-EP) 的严重喘.
主要成果:
- 在最佳的SGC剂量和逐渐减少策略上达成共识.
- 关于生物制剂作为SGC节约剂的启动标准的协议.
- 有证据表明,生物制剂可以有效地减少SGC负担.
结论:
- 针对IL-5的生物疗法提供了一种有希望的方法,可以减少SGC在eosinophilic疾病中的使用.
- 早期引入生物药物可以防止与中长期SGC治疗相关的不良影响.
- 专家共识为管理SGC和将生物制剂纳入临床实践提供了指导.
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