尽管从瘤性肠结肠炎中恢复过来,婴儿仍然对受伤有过度炎症反应
Katherine B Snyder1,2, Chase L Calkins3, Alena Golubkova1,2
1Division of Pediatric Surgery, Oklahoma City, OK, 73104, USA.
Journal of inflammation research
|January 22, 2024
概括
在早产婴儿中,死性肠球炎 (NEC) 与炎症反应加剧有关. 即使在康复后,受NEC影响的肠细胞在暴露于刺激时也会出现炎症增加,这表明对严重反应的倾向.
科学领域:
- 新生儿科学 新生儿科学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 死性肠球炎 (NEC) 是早产新生儿的主要死亡原因.
- NEC的特点是早产,高炎症和肠道屏障功能受损.
- 在NEC患者中假设持续的超炎性肠道反应.
研究的目的:
- 研究新生儿的肠组织和肠膜中的炎症反应,有或没有NEC.
- 为了比较康复的NEC患者与对照者的炎症标志物.
- 评估二次炎症刺激对与NEC相关的体的影响.
主要方法:
- 从患有NEC的新生儿,恢复的NEC和对照的新生儿的肠道组织中产生了体.
- 体被暴露于脂多糖 (LPS) 和缺氧.
- 使用RT-qPCR和ELISA测量了瘤坏死因子-alpha (TNF-α) 和中白素-8 (IL-8) 的表达.
主要成果:
- 在恢复的NEC组织和非NEC组织之间,炎症标志物没有显著差异.
- 与对照组相比,在LPS/低氧治疗后,恢复的NEC体显示出明显更高的炎症标志物水平 (TNF-α,IL-8).
- 与未经治疗的恢复过来的NEC体相比,经过治疗的恢复过来的NEC体显示炎症标志物增加,这表明对二次侮辱的反应加剧.
结论:
- 具有活性NEC的新生儿的肠道组织显示炎症反应升高.
- 来自康复的NEC患者的内体显示出对NEC诱导刺激的炎症反应加剧.
- 这种高炎症倾向可能使婴儿易患NEC,并影响康复后的疾病轨迹.
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