基于正念的认知治疗与精神教育干预对血大脑衍生的神经变因子和双极性患者认知功能的影响:一项随机对照试验
Diego Carracedo-Sanchidrian1,2, Consuelo de Dios-Perrino1,2,3, Carmen Bayon-Perez1,2,3
1Department of Psychiatry, University Hospital La Paz, Madrid, Spain.
Frontiers in psychiatry
|January 22, 2024
概括
基于正念的认知疗法 (MBCT) 对双相情感障碍 (BD) 患者的认知功能或来自大脑的神经营养因子 (BDNF) 没有显著改善,与精神教育或通常治疗 (TAU) 相比. 这项研究表明,干预的持续时间可能会影响结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 双极性障碍 (BD) 显著影响认知功能和来自大脑的神经营养因子 (BDNF) 水平.
- 对照试验调查基于正念的认知疗法 (MBCT) 对于这些BD的特定结果是有限的.
研究的目的:
- 评估MBCT作为辅助治疗认知功能和双相情感障碍患者血清BDNF水平的疗效.
- 为了比较MBCT对精神教育和通常治疗 (TAU) 的影响.
主要方法:
- 一个随机的,多中心的,单盲试验,涉及84名BD门诊患者.
- 三个分支:MBCT + TAU,精神教育 + TAU,和单独的TAU.
- 通过多个标准化测试评估认知功能;在基线,8周和6个月以ELISA测量BDNF水平.
主要成果:
- 在MBCT,精神教育和TAU组之间没有观察到认知功能或BDNF水平的显著差异.
- 在研究结果中,MBCT的表现并没有超过精神教育或TAU.
结论:
- 在这项试验中实施的MBCT并没有显示出比精神教育或TAU在认知功能和双相情感障碍中的BDNF方面具有优越的益处.
- 由于MBCT干预的持续时间有限,以及心理教育和TAU的有效性已经得到证实,这可能解释了这些发现.
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