显著的刺激和抑制块在随机神经场中漫步
Heather L Cihak1, Tahra L Eissa1, Zachary P Kilpatrick1
1Department of Applied Mathematics, University of Colorado Boulder, Boulder, CO 80309 USA.
SIAM journal on applied dynamical systems
|January 22, 2024
概括
这项研究模拟了工作记忆神经活动,揭示了激发性和抑制性神经元相互作用以及噪声相关性如何影响记忆回忆的准确性. 神经元类型之间的更高相关性令人惊地减少了记忆差异.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 认知科学 认知科学
背景情况:
- 参数性工作记忆依赖于局部持续的皮质神经活动,称为神经凸起.
- 现有的模型往往简化了神经群体,忽视了激发性 (金字塔) 和抑制性 (神经间) 亚群体的不同作用.
- 人口间神经架构和噪声相关性对神经碰撞动态的影响仍未得到充分研究.
研究的目的:
- 调查单独的刺激和抑制神经子群对工作记忆动态的影响.
- 分析人群间神经架构和噪声相关性在塑造神经突起行为的作用.
- 推导出一个捕捉这些复杂神经相互作用的数学模型.
主要方法:
- 开发了一个神经场模型,包含了不同的刺激和抑制群体.
- 采用了非对称分析来导出一个非线性朗格温系统,用于碰撞相互作用.
- 研究了在子群体内和子群体之间噪音相关性对碰撞动态的影响.
主要成果:
- 激发性突会吸引抑制性突,而抑制性突可以稳定或击退激发性突.
- 由于这些相互相互作用,扰动会导致延长放松动态.
- 噪音相关结构显著影响撞击位置的方差,较高的人群间相关性意外地减少了方差.
结论:
- 独特的刺激和抑制神经群体动态对于理解工作记忆至关重要.
- 人口间的神经架构和噪声相关性在塑造行为反应变异方面发挥着重要作用.
- 这些发现挑战了简化的模型,并强调了详细的神经架构在工作记忆等认知功能中的重要性.
相关概念视频
01:25Neural Circuits
1.2K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.2K
01:19The Role of Ion Channels in Neuronal Computation
3.2K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.2K
01:29Excitatory and Inhibitory Effects of Neurotransmitters
10.0K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
10.0K
01:31Action Potential
8.0K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
8.0K
01:22Muscle Stimulation Frequency
2.2K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.2K
01:28Action Potential: Phases of Stimulation
5.8K
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
5.8K