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Updated: Jul 3, 2026

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy
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揭示内在无序蛋白c-Myc的行为:利用高斯加速分子动力学的研究

Kavinda Kashi Juliyan Gunasinghe1, Taufiq Rahman2, Xavier Chee Wezen1

  • 1Faculty of Engineering, Computing and Science, Swinburne University of Technology Sarawak, Kuching 93350, Malaysia.

ACS omega
|January 22, 2024
PubMed
概括

这项研究揭示了c-Myc/Max异构体模型,表明c-Myc bHLH-Zipper动机在与Max结合时更稳定. 这为开发针对癌症中c-Myc等内在无序蛋白质的药物提供了见解.

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Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
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Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...