在T2DMCOVID患者中,相关的D-Dimer,血糖,血红蛋白和肝功能
Balaji Viswanatha Setty1, Gutlur Nagarajaiah Setty Raghav1, Hareesh Rangaswamaiah1
1Department of General Medicine, Rajarajeshwari Medical College and Hospital, Bangalore, Karnataka, India.
在2型糖尿病患者中,COVID-19显著提高了血糖,肝酶和D-二次体水平,特别是那些有症状的人. 对这些标记物的持续监测对于管理糖尿病和COVID-19至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 血液学 血液学 血液学
背景情况:
- 2型糖尿病 (T2DM) 是严重的COVID-19结局的重要危险因素.
- 在T2DM患者中,SARS-CoV-2感染和代谢失调之间的相互作用需要进一步阐明.
- 了解T2DM中与COVID-19相关的生物化学变化对于患者管理至关重要.
研究的目的:
- 调查T2DM患者与没有COVID-19症状的D-二聚合物,血糖,血红蛋白和肝功能测试 (LFTs) 之间的相关性.
- 评估COVID-19对T2DM患者血糖控制和肝功能的影响.
- 评估COVID-19的T2DM患者中D-二次体水平和疾病严重程度 (CT值) 之间的关系.
主要方法:
- 招募了200名有COVID-19和没有COVID-19的T2DM患者队列.
- 所有参与者都进行了血糖,HbA1c,D-二元和肝功能测试.
- 在生物化学参数和临床数据之间进行了相关性分析,包括CT值.
主要成果:
- 与无症状患者相比,患有T2DM和症状COVID-19的患者表现出显著升高的生物化学参数 (P<0.05).
- D-二聚合物水平与CT值呈正相关性 (r=0.518,P<0.05).
- 发现COVID-19可以增强胰岛素耐药性,高血糖和肝脏异常,同时促进血栓溶解.
结论:
- 新型冠状病毒感染加剧T2DM患者的高血糖和胰岛素抵抗.
- 在T2DM患者中,COVID-19可能导致肝功能异常,并促进T2DM患者的血栓形成状态 (血栓溶解).
- 对于有或没有COVID-19症状的T2DM患者,建议对D-二聚体和LFT进行持续监测.
更多相关视频
06:46A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
