在亚慢性暴露于HTP气溶和香烟烟雾后,大鼠的肝毒性
Yushan Tian1,2,3, Hongjuan Wang1,2,3, Shulei Han1,2,3
1Beijing Life Science Academy, Yingcai South 1st Street, Beijing 102209, China.
Toxicology research
|January 22, 2024
概括
加热的烟草制品 (HTP) 和香烟烟雾 (CS) 影响肝脏. 虽然这两种药物都会引起炎症和氧化应激,但在相当的尼古丁水平下,HTPs对肝脏的毒性风险可能低于CS.
科学领域:
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
- 吸入暴露 吸入暴露
背景情况:
- 加热烟草制品 (HTP) 是一种新的尼古丁输送系统.
- 热烟被推销为传统香烟的潜在更安全的替代品.
- 肝脏在代谢吸入化合物的作用需要评估HTP的肝脏作用.
研究的目的:
- 为了研究HTP气溶和香烟烟雾 (CS) 对Sprague-Dawley (SD) 鼠的肝脏的亚慢性影响.
- 为了比较HTP和CS暴露对肝功能和病理学的毒理学概况.
主要方法:
- 低慢性吸入研究 (OECD 413) 使用SD大鼠.
- 暴露组:沙姆 (空气),HTP (10,23,50微克尼古丁/L) 和CS (23微克尼古丁/L).
- 对临床病理,炎症,氧化应激和肝脏组织病理学的评估.
主要成果:
- 在雄性大鼠中,HTP (50微克尼古丁/L) 和CS (23微克尼古丁/L) 改变了氨酸转移酶 (ALT).
- 无论是HTP还是CS暴露都减少了IL-1β,IL-6,TNF-α和线粒体氧化应激.
- CS暴露减少了ATP的产生,并导致肝细胞胀;HTP (50微克尼古丁/L) 显示病理变化,但没有亡.
结论:
- 通过线粒体的氧化应激和炎症,CS会诱导肝脏损伤.
- 高度的HTP暴露也会引起炎症和氧化应激.
- 在相当的尼古丁度下,HTP与CS相比,可能对肝脏产生较低的毒性作用.
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