设计一种药物排泄的眼部贴片,用于输送和持续释放抗炎治疗药物
Xi Chen1, Shima Gholizadeh1, Mahsa Ghovvati1
1Department of Chemical and Biomolecular Engineering, University of California- Los Angeles, Los Angeles, CA, USA.
AIChE journal. American Institute of Chemical Engineers
|January 22, 2024
概括
一种新的水凝眼部贴片可以有效地为15天提供药物. 这种生物相容的GelPatch提供了持续释放的疏水药物,克服了眼部药物输送方面的挑战.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 眼部炎症是眼部疾病和损伤的常见并发症.
- 由于生理和结构障碍,很难实现对眼睛的有效和持续的治疗.
- 疏水性药物对眼部施用具有独特的挑战.
研究的目的:
- 设计一个可光交联的粘合性水凝贴片 (GelPatch),用于持续的眼部药物输送.
- 在GelPatch中加入装有Loteprednol etabonate (LE) 的小粒 (MC),以提高药物的溶解性和释放性.
- 评估开发的眼部药物输送系统的物理特性,药物释放动力学和生物相容性.
主要方法:
- 制造一个可光交叉连接的粘合剂水凝贴片 (GelPatch).
- 在GelPatch矩阵中将装载有Loteprednol etabonate (LE) 的小粒细胞 (MC) 纳入.
- 通过在老鼠体内进行皮下植入,评估药物释放特征,细胞活性的*in vitro*和生物相容性的*in vivo*.
主要成果:
- 工程设计的GelPatch表现出对眼睛表面的高度粘附性和受控的物理性质.
- 装有MC的GelPatch促进了LE的溶解,并在15天内实现了持续的药物释放.
- *体外*研究证实了GelPatch支持的细胞活力, *体内*研究显示了28天的良好生物相容性和稳定性.
结论:
- 开发的GelPatch是一种有前途的非侵入性,粘合性和生物相容性平台,用于眼部药物输送.
- 这种系统有效地实现了疏水药物的持续释放,解决了眼科医学的关键需求.
- 凝贴技术为治疗眼部炎症和其他需要长期药物治疗的眼部疾病提供了潜在的进步.
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