利用免疫力来治疗晚期甲状腺癌
Hiroki Komatsuda1, Michihisa Kono1,2, Risa Wakisaka1
1Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa 078-8510, Japan.
Vaccines
|January 22, 2024
概括
甲状腺癌 (TC) 治疗方法,如放射性治疗,仅限于晚期的癌症. 免疫疗法通过向甲状腺癌中的免疫抑制来显示有希望的结果,为患者提供了新的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 甲状腺癌 (TC) 发病率正在上升,差异化甲状腺癌 (DTC) 通常是可以治疗的,但有时会转移.
- 无塑性甲状腺癌 (ATC) 的预后不佳,治疗选择有限.
- 氨酸激酶抑制剂 (TKIs) 显示有效性,但获得的耐药性是常见的.
研究的目的:
- 审查当前对甲状腺癌免疫微环境的理解.
- 探索瘤微环境中的免疫抑制机制.
- 突出免疫学目标和免疫疗法在甲状腺癌治疗中的潜力.
主要方法:
- 关于甲状腺癌免疫学和免疫治疗的当前文献的综述.
- 分析甲状腺癌中免疫逃避和抑制机制.
- 评估新兴的免疫治疗策略和目标.
主要成果:
- 甲状腺癌,特别是ATC,表现出由瘤细胞和相关免疫细胞介导的复杂免疫抑制.
- 关键的免疫抑制因素包括负免疫检查点,VEGF和IDO1.
- 免疫疗法的进步,包括免疫检查点抑制剂 (ICI),有可能克服免疫抑制.
结论:
- 免疫疗法代表了甲状腺癌的有希望的治疗途径,特别是在耐药或晚期病例中.
- 针对瘤的免疫微环境和克服免疫抑制对于有效治疗至关重要.
- 涉及免疫疗法的组合疗法可能会增强甲状腺癌的抗瘤反应.
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