比芬林通过诱导小鼠精子中的蛋白质缺陷来降低男性生育潜力
Jeong-Won Bae1, Ju-Mi Hwang1, Minjung Yoon1,2
1Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Gyeongsangbuk-do, Republic of Korea.
Toxics
|January 22, 2024
概括
暴露于比芬林农药会通过降低精子的运动和功能而不是生命力而损害男性的生育能力. 分子分析显示了精子结构和新陈代谢至关重要的蛋白质的变化.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 分子生物学分子生物学
背景情况:
- 合成的类杀虫剂,如双氨酸,被广泛用于害虫控制.
- 越来越多的双氨酸使用引发了人们对环境和公共卫生影响的担忧,特别是对生殖的影响.
研究的目的:
- 为了研究双林对精子功能的影响背后的分子机制.
- 为了识别受双林暴露影响的特定精子蛋白和途径.
主要方法:
- 流行性精子被暴露在不同度的双氨酸 (0.1,1,10,100微米).
- 评估了精子的活力,运动性,体反应和容量.
- 进行蛋白质组分析以确定差异表达的蛋白质.
主要成果:
- 双林并没有影响精子的活力,但显著降低了运动性,自发的体反应和从1μM开始的电容性.
- 鉴定出九种不同表达的精子蛋白质,涉及移动膜组装,精子结构和代谢过程.
- 比芬林暴露导致关键精子蛋白的表达异常减少.
结论:
- 双氨酸通过破坏分子水平上关键的精子功能,对男性生育能力产生负面影响.
- 该研究阐明了特定蛋白质表达的变化,有助于双林诱导的男性生殖毒性.
更多相关视频
03:19Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
438
06:38Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
15.5K
相关概念视频
01:23Infertility in Males
265
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
265
01:41Spermatogenesis
102.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.5K