基于纳米材料的先进生物传感器用于N-终端前脑天然尿素生物标记物检测:心血管疾病诊断的进展和未来挑战
Yen-Yi Lee1,2,3, Balasubramanian Sriram4, Sea-Fue Wang4
1Institute of Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833301, Taiwan.
Nanomaterials (Basel, Switzerland)
|January 22, 2024
概括
纳米材料生物传感器在检测N-终端B型亲尿素 (NT-proBNP) 以诊断心力衰竭 (HF) 方面表现有前途. 在成本,灵敏度和广泛使用的临床整合方面仍然存在挑战.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 心脏病学 心脏病学
背景情况:
- 心血管疾病 (CVD) 构成了全球卫生挑战,需要改进诊断工具.
- N-终端亲B型尿素 (NT-proBNP) 是CVD预后的关键生物标志物,特别是心力衰竭 (HF).
研究的目的:
- 审查基于纳米材料的生物传感器在CVD和HF中检测NT-proBNP的进步和局限性.
- 确定临床翻译的关键挑战和未来研究方向.
主要方法:
- 文献综述侧重于用于NT-proBNP检测的纳米材料 (石墨烯衍生物,量子点,金属纳米粒子).
- 对诊断灵敏度,特异性和检测值的分析.
- 评估挑战,包括临床敏感性,成本和部署.
主要成果:
- 新型纳米材料显著提高了NT-proBNP检测的灵敏度和特异性,降低了HF诊断的检测极限.
- 关键的挑战包括实现临床级敏感性,高生产成本和在医疗保健环境中实际实施.
结论:
- 纳米材料生物传感器在高频诊断方面具有变革性的潜力.
- 进一步的研究对于优化合成,降低成本,提高可用性,以及为临床整合寻找监管途径至关重要.
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