阿尔布特罗尔对患有喘儿童呼吸能力的急性影响
Michael W H Wong1, Lung-Chang Chien2, Dharini M Bhammar3
1Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
在运动测试之前,阿尔布特在患有喘的儿童中增加了估计的呼吸能力. 这可能有助于预防心肺运动测试 (CPET) 期间的症状和早期测试完成.
科学领域:
- 儿科肺病学 儿科肺病学
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有喘的儿童经常表现出呼吸能力下降,这可能会限制心肺运动测试 (CPET) 持续时间.
- 在CPET期间的症状可能会导致儿童喘患者过早终止测试.
研究的目的:
- 调查短效β-激动剂 (阿尔布特醇) 对喘儿童估计呼吸能力的影响.
- 为了确定阿尔布特罗尔的使用是否可以改善CPET的运动前呼吸功能.
主要方法:
- 一项涉及15名患有喘的儿童 (平均年龄10.6岁) 的横截面研究.
- 螺旋测量和通风容量计算 (FVC/2 × [60/(2 × isoFET25-75)) 在基线,阿尔布托罗尔后和CPET后进行.
- 重复测量混合模型与邦费罗尼校正分析结果变量差异.
主要成果:
- 与基线 (60.9 L/min) 相比,估计的呼吸能力在阿尔布特罗尔 (68.7 L/min) 和CPET后 (75.8 L/min) 显著增加.
- 通风能力的增加归因于ISOFET25-75 (中流量增加) 的减少,因为强迫生命能力保持不变.
- 阿尔布特罗尔的使用表明,在CPET前对呼吸能力产生积极影响.
结论:
- 在患有喘的儿童中,在CPET之前服用阿尔布托罗尔可能是有益的,特别是那些FEV1.1保存的儿童.
- 运动前的阿尔布特罗尔可以提高呼吸能力,可能减少CPET的症状有限的早期终止.
- 考虑使用阿尔布特罗尔作为CPET前干预措施,以优化儿童喘的测试.
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