代谢功能障碍相关的脂肪肝疾病和慢性病毒性肝炎:相互联系
Cornelius J Fernandez1, Mohammed Alkhalifah2,3,4, Hafsa Afsar2
1Department of Endocrinology and Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston PE21 9QS, UK.
Pathogens (Basel, Switzerland)
|January 22, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 影响全球三分之一的人口. 本综述探讨了MAFLD如何与慢性病毒性肝炎B和C相互作用,影响肝病进展和患者管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题,由肥胖流行病驱动.
- 由乙型肝炎病毒 (HBV) 和型肝炎病毒 (HCV) 引起的慢性病毒性肝炎仍然是全球肝病的重要原因.
- MAFLD与慢性病毒性肝炎的同时发生在诊断和管理方面带来了复杂的挑战.
研究的目的:
- 审查MAFLD和慢性病毒性肝炎 (HBV和HCV) 之间的复杂相互作用.
- 阐明病毒性肝炎影响代谢功能障碍的机制.
- 检查MAFLD对病毒性肝炎相关肝病自然史和进展的影响.
主要方法:
- 临床研究和病理生物学研究的综合文献综述.
- 分析病毒性肝炎中介的代谢功能障碍背后的机制.
- 评估MAFLD对病毒性肝炎患者肝病进展的影响.
主要成果:
- MAFLD显著影响慢性HBV和HCV感染的过程和治疗.
- 慢性病毒性肝炎可以加剧代谢功能障碍,并使MAFLD复杂化.
- 了解这些相互作用对于有效的患者护理至关重要.
结论:
- MAFLD和慢性病毒性肝炎的结合需要一个细微的临床方法.
- 对病理生物学相互作用的进一步研究对于开发向疗法至关重要.
- 综合管理策略对于改善MAFLD和病毒性肝炎同时存在的患者的治疗结果至关重要.
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