巴特尔指数,SPAN-100和NIHSS关于血栓溶解患者预后预测价值的研究
Meng Fu1, Yani Fan2, Shuangmei Yan3
1The Third Hospital of Hebei Medical University.
The neurologist
|January 22, 2024
概括
巴特尔指数 (BI) 有效地预测了急性缺血性中风 (AIS) 患者接受血栓治疗的预后. 较低的BI分数表明较差的结果,在预测准确度方面表现优于NIH中风量表 (NIHSS) 和SPAN-100.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 脑卒中研究 脑卒中研究
背景情况:
- 评估急性缺血性中风 (AIS) 患者的预后,这些患者正在接受血栓缓解疗法,对于治疗决策至关重要.
- 像国家卫生研究院中风量表 (NIHSS) 和SPAN-100这样的现有量表在预测结果方面存在局限性.
- 巴特尔指数 (BI) 是一种广泛使用的功能独立度量,但其在血栓溶解性AIS患者的预测价值需要进一步研究.
研究的目的:
- 评估巴特尔指数 (BI),SPAN-100和美国国立卫生研究院中风量表 (NIHSS) 的临床预后和功能结果的预测价值,用于治疗AIS的血栓治疗患者.
- 将这三个尺度的预测性能进行比较,以确定在这个患者群体中评估预后的最有效工具.
主要方法:
- 分析了一组212名初发性AIS患者的队列,这些患者接受了复合组织等离子体激活剂 (rt-PA) 血栓溶解.
- 患者在出院时分为预后良好 (修改兰金尺度[mRS] ≤2) 和预后不佳 (mRS ≥3) 的两组.
- 用物流多变量分析和接收器运行特征 (ROC) 曲线分析与曲线下面积 (AUC) 计算来比较BI,NIHSS和SPAN-100的预测准确性.
主要成果:
- 巴特尔指数 (BI) 成为接受血栓溶解的AIS患者预后不佳的重要预测指标;较低的BI分数与较差的结果相关.
- BI 的AUC为0.862,明显高于NIHSS (AUC=0.665) 和SPAN-100 (AUC=0.640) 的AUC.
- 在BI和NIHSS (P < 0.00001) 之间以及在BI和SPAN-100 (P < 0.00001) 之间发现了统计学上显著的差异,而在NIHSS和SPAN-100 (P = 1.7997) 之间没有观察到显著差异.
结论:
- 简单的巴特尔指数 (BI) 评分表明,急性缺血性中风 (AIS) 患者的血栓治疗具有高预后价值.
- BI是一个比NIHSS和SPAN-100更有效的工具,用于预测这个患者群体的功能结果.
- 常规使用BI可以帮助临床医生评估和管理接受血栓溶解的AIS患者.
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