在转移性黑色素瘤中接受系统治疗的差异
Hanna Kakish1, Omkar Pawar1, Maira Bhatty2
1Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center.
American journal of clinical oncology
|January 22, 2024
概括
系统疗法可以改善转移性黑色素瘤患者的生存率,但治疗差异仍然存在. 需要采取努力,确保所有人平等地获得这些救命治疗.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 医疗保健服务研究 医疗服务研究
背景情况:
- 自2011年以来,免疫疗法和向疗法已经改变了黑色素瘤的治疗方法.
- 治疗不平等可能会阻止一些患者充分受益于这些进步.
研究的目的:
- 调查第四阶段黑色素瘤的系统治疗使用趋势.
- 为了确定与治疗遗漏相关的因素.
- 评估治疗对整体存活时间的影响.
主要方法:
- 来自国家癌症数据库的19961名第四阶段黑色素瘤患者的回顾性审查.
- 两个时间段的比较:2004-2010年和2016-2020年.
- 使用卡普兰-梅尔方法分析治疗接收,缺失因子和整体存活率.
主要成果:
- 没有接受全身治疗的患者比例从54.9% (2004-2010) 降至28.3% (2016-2020),到2020年停滞在25%左右.
- 系统治疗显著改善了这两个时期的平均整体存活率 (例如,在2016-2020年为25.9个月而不是4.3个月).
- 放弃治疗与较低的社会经济地位,缺乏保险以及在较低数量的或非学术中心接受治疗有关.
结论:
- 系统疗法为转移性黑色素瘤提供了显著的生存益处.
- 接受治疗的差异仍然是一个关键问题.
- 有针对性的本地干预措施是必要的,以确保公平获得有效的黑色素瘤治疗.
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