爪皮肤透视预测缺少毛细血管透视硬化皮肤模式:多中心,前性VASCUL-R试验
Jean-Benoît Monfort1, Tiffany Klejtman2, Isabelle Lazareth2
1Service de Dermatologie et Médecine Vasculaire, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Sorbonne Université, Paris, France.
概括
在雷诺现象 (RP) 患者中,正常的指甲折叠皮层扫描有效预测正常的指甲折叠视频毛细膜扫描 (NVC). 缺少特定的皮肤透视标准表明毛细血管的健康模式,有助于RP诊断.
科学领域:
- 血管医学 血管医学
- 皮肤病学 皮肤病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 爪毛细膜镜对于诊断雷诺现象 (RP) 是至关重要的.
- 主要RP往往呈现出正常的毛细管镜检查结果.
- 爪皮肤镜显示了查RP相关的毛细血管异常的前景.
研究的目的:
- 评估正常的指甲折叠皮肤镜能否预测正常的指甲折叠视频毛囊镜 (NVC).
- 为了确定正常NVC正常皮肤镜的正预测值 (PPV).
主要方法:
- 前性,两阶段 (单中心和多中心) 的研究.
- 105名患有雷诺现象 (RP) 的患者接受了NVC和指甲折叠皮肤镜检查.
- 盲目观察者评估了五个特定的标准:组织不整,超大毛细血管,毛细血管密度低,无血管区域和出血.
主要成果:
- 正常皮肤镜检查显示,正常NVC的百分之百PPV (p=0.015).
- 除了出血外,PPV仍然为100% (p<0.0001),敏感度为73.7%,特异性为100%.
结论:
- 正常的指甲折叠皮肤镜,由于没有四个标准,可以准确地预测正常的NVC.
- 这种方法为诊断初级RP提供了极好的积极预测价值.
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