深度大脑刺激通过准thalamic感觉运动连接来改善性失声症的症状
Michael G Hart1, Nancy Polyhronopoulos2, Mandeep K Sandhu2
1St George's, University of London & St George's Hospitals NHS Foundation Trust, Institute of Molecular and Clinical Sciences, Neurosciences Research Centre, London, UK.
Neurosurgery
|January 22, 2024
概括
对于性失声症的深度大脑刺激 (DBS) 有效地准了thalamic感觉运动区域. 这种方法调节失调的大脑电路,改善声带功能和言语.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 语言病理学 语音病理学
背景情况:
- 性失声症是一种声带失声症,影响言语.
- 目前的理论表明,体感官运动集成失调.
- 在此之前,thalamic深脑刺激 (DBS) 已经显示出安全性和有效性.
研究的目的:
- 为了预测性失声症治疗结果.
- 为了研究体感觉运动区域和白质通道在DBS疗效中的作用.
- 为了将刺激参数与临床改善相关联.
主要方法:
- 研究了6名患有添加器性失声症的参与者,他们接受了thalamic DBS.
- 使用Lead-DBS工具箱定位电极并执行基于voxel的症状映射.
- 利用扩散张力成像用于大脑脑和脑道管道的曲谱.
主要成果:
- 有效的DBS接触激发了比无效的更多的乳头感觉运动区域.
- 分析没有发现一个单一的"甜点",表明单个区域的调制.
- 一年后的随访显示,预测的感觉运动区域和大脑支路的刺激.
结论:
- thalamic感觉运动区域的刺激与性失声症症状的改善相关.
- 这些发现支持DBS对失调的乳头感官运动集成起作用.
- 对感觉运动通路的个性化刺激是有效的DBS治疗的关键.
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