同时使用大麻和阿片类药物依赖的人群中神经认知功能障碍:一个横断的,受控的研究
Abhishek Ghosh1, Alka Shaktan1, Abhishek Verma1,2
1Drug Deaddiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Journal of psychoactive drugs
|January 22, 2024
概括
大麻和阿片类药物共同依赖显著损害认知功能,特别是工作记忆和执行功能. 这项研究突出了同时出现物质使用障碍的个体的神经认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 阿片类药物依赖 (OD) 和大麻依赖 (CD) 独立地与认知缺陷有关.
- 同时使用物质可能会加剧神经认知障碍.
研究的目的:
- 研究与阿片类药物依赖和大麻依赖 (OD+CD) 或大麻使用 (OD+CU) 同时存在的人群中的神经认知功能障碍.
- 将认知表现与只有阿片类药物依赖 (OD) 和健康对照 (HC) 的人进行比较.
主要方法:
- 招募的参与者被诊断为OD (N=268),OD+CU (N=58),OD+CD (N=115),和教育匹配的HC (N=68).
- 进行了一系列神经认知测试,包括SPM,WCST,IGT,TMT A/B和口头/视觉工作记忆1和2回测试.
- 分析了群体之间的绩效差异,考虑到人口因素.
主要成果:
- 与HC相比,OD和OD+CD组在WCST上表现出明显更高的非持续性错误.
- OD+CD组在WCST上完成的类别比HC更少.
- 所有患者组 (OD,OD+CU,OD+CD) 在视觉工作记忆1-back中显示出较高的委员会错误,与HC相比.
- HC组在口头工作记忆2-back中的错误比OD和OD+CD组要少得多.
- 与HC相比,OD+CU组在TMT B上表现出较少的错误.
结论:
- 大麻和阿片类药物共同依赖显著导致认知障碍.
- 在患有阿片类药物和大麻使用障碍同时出现的人群中,工作记忆和执行功能特别受到影响.
- 调查结果强调了在临床干预中解决多物质使用在认知康复中的重要性.
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