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在妊娠前中潜在的尿路生物标志物:叙述性综述

Renata Araujo Avendanha¹, Guilherme Figueiredo Coelho Campos¹, Beatriz Castello Branco^1,2

¹Liga Acadêmica de Pesquisa Científica, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Molecular biology reports

|January 22, 2024

概括

尿路生物标志物显示出预测妊娠前 (PE) 的前景. 虽然传统的标记物有所不同,但像胎盘生长因子 (PlGF) 和尿液中的sFlt-1/PlGF比率等新型标记物对早期查和诊断有希望.

科学领域:

产科和妇科产科和妇科
腎臟病學 (nephrology) 是一種醫學專業.
生物标志物发现发现

背景情况:

孕前 (PE) 是一种严重的怀孕疾病,需要及早诊断以预防孕产妇和新生儿的并发症.
功能障碍与PE病理生理学有关,使尿液分析成为最小侵入性生物标志物的潜在来源.
识别新的尿路生物标志物可以显著改善PE预测和管理结果.

研究的目的:

审查和总结现有关于产前症 (PE) 传统和潜在尿路生物标志物的文献.
研究这些尿路生物标志物在查和诊断PE中的适用性.
突出有希望的新生物标志物,以改善PE预测.

主要方法:

在主要的科学数据库中进行了非系统的文献搜索:PubMed/MEDLINE,Scopus和SciELO.
审查的重点是评估PE预测传统血清标志物和新型尿路生物标志物的研究.
分析包括与功能相关的生物标志物,生长因子,蛋白质负载和先进的奥米克技术.

主要成果:

传统的血清标记物,如肌素,囊素C和白色素尿,对于PE预测显示不一致的准确性.
尿性胎盘生长因子 (PlGF) 和可溶性fms类氨酸激酶 (sFlt-1) /PlGF比率表现出作为查工具的希望.
尿道凝血症, podocyturia, nefrinuria,蛋白质组和代谢组显示出精确的PE查和诊断的潜力.

结论:

尿路生物标志物,特别是plgf和sflt-1/plgf比率,显示出对孕前的查和诊断有很大的潜力.
像蛋白质学和代谢学这样的先进技术在预测PE发展和严重程度方面提供了高准确度.
需要进一步的结论性研究来解决现有的文献差异,并确认这些尿路生物标志物的预测作用.

关键词:

孕前症孕前症怀孕怀孕怀孕怀孕功能功能功能尿路生物标志物尿路生物标志物

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