1型糖尿病的自身免疫性并发症及其与年轻人代谢控制和死亡风险的关联:基于人口的研究
John Samuelsson1,2, Rebecka Bertilsson3, Erik Bülow3,4
1Department of Paediatrics, Ryhov County Hospital, Jönköping, Sweden. john.samuelsson@rjl.se.
Diabetologia
|January 22, 2024
概括
患有1型糖尿病的儿童和年轻人患有自身免疫性疾病的患病率很高,尤其是乳和甲状腺疾病. 然而,这些并发症并没有显著影响血糖控制 (HbA1c) 或增加死亡风险.
科学领域:
- 内分泌学和新陈代谢学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 1型糖尿病 (T1D) 是一种自身免疫性疾病,通常与其他自身免疫性并发症有关.
- 了解这些伴随性疾病在年轻T1D患者中的范围和影响,对于全面的护理至关重要.
- 以前的研究没有全面评估儿童群体T1D发病后各种自身免疫疾病的长期发展.
研究的目的:
- 描述被诊断为1型糖尿病的儿童和年轻成年人自身免疫性并发症的发生率和类型.
- 调查T1D患者自身免疫性并发症和血糖控制 (HbA1c) 之间的关联.
- 检查年轻T1D队列中自身免疫共发病和死亡风险之间的关系.
主要方法:
- 一项基于登记的全国性队列研究,利用瑞典国家糖尿病登记册.
- 包括15188名在18岁之前被诊断患有T1D的人 (2000年至2019年),与人口对照相匹配.
- 通过国家患者登记册的ICD-10代码识别的自身免疫性疾病;死亡原因登记册的死亡数据.
主要成果:
- 19.2%的T1D患者被诊断出患有至少一种自身免疫性疾病,而对照组的4.0%.
- 对于乳病 (11.6),甲状腺病 (10.6),阿迪森病 (18.3) 和缩性胃炎 (19.6) 观察到的高危险比率 (HRs).
- 在T1D患者的自身免疫性并发症没有显示出对HbA1c水平或死亡风险的统计学上显著影响.
结论:
- 这项研究证实了T1D年轻人的自身免疫性疾病的高患病率,尤其是乳和甲状腺疾病.
- 在这种队列中,自身免疫性并发症的存在似乎不会对代谢控制或长期存活产生负面影响.
- 研究结果强调了儿童T1D患者自身免疫疾病查的重要性,并表明T1D本身的管理对结果至关重要.
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