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Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Humoral Immune Responses01:36

Humoral Immune Responses

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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Updated: Jul 5, 2025

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

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精英运动员的补充系统缺陷

Libor Vítek1,2, Jana Woronyczova3,4, Veronika Hanzikova5

  • 1Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Kateřinská 32, 120 00, Prague, Czech Republic. vitek@cesnet.cz.

Sports medicine - open
|January 22, 2024
PubMed
概括

精英运动员经常出现补充系统缺陷,包括较低的C3和C4水平以及经典和替代途径激活的缺陷. 这些发现表明,对传染病易感性的潜在影响.

关键词:
补充 补充 补充 补充补充疗法是一种补充疗法.精英运动员的精英运动员.运动运动运动.运动运动运动运动运动.

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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

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相关实验视频

Last Updated: Jul 5, 2025

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科学领域:

  • 免疫学 免疫学 免疫学
  • 运动医学 运动医学
  • 生物化学 生物化学

背景情况:

  • 定期体育活动可以增强免疫功能,减少炎症.
  • 精英运动员的强度训练可以增加对感染的易感性.
  • 补体系统在免疫防御中起着至关重要的作用.

研究的目的:

  • 评估精英运动员的补充系统参数.
  • 为了比较精英运动员和健康对照者之间的补充成分度和通路激活.

主要方法:

  • 测量了C3,C4和曼诺结合性莱克 (MBL) 的血清度.
  • 确定了古典,替代和莱克补充通路的激活.
  • 研究了134名精英运动员和110名健康对照者的队列.

主要成果:

  • 与对照人群相比,精英运动员的C3和C4度明显较低.
  • 在运动员中观察到C3和C4缺乏的频率更高.
  • 运动员在经典和替代补充通路激活方面出现了较高的缺陷率.

结论:

  • 在精英运动员中存在补充系统缺陷的高患病率.
  • 较低的C3/C4水平和经典/替代途径缺陷是常见的.
  • 需要进一步的研究,以了解对传染病风险的临床影响.