CXC联接体13调节一个免疫活性微环境,并增强在头部和部状细胞癌的免疫治疗反应
Xiaohu Lin1,2,3,4, Xiaomei Zhao1,2,3,4, Yiming Chen1,2,3,4
1Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
International journal of immunopathology and pharmacology
|January 22, 2024
概括
化学物质CXCL13 (CXCL13) 在头部和部状细胞癌 (HNSCC) 中被上调,与更好的预后和增强的免疫疗法反应相关. 它的表达与免疫细胞激活和三级淋巴体结构 (TLS) 有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一个重要的全球健康问题.
- 了解瘤微环境在HNSCC进展和治疗反应中的作用至关重要.
研究的目的:
- 系统地研究化学因子CXC合体13 (CXCL13) 在HNSCC中的作用.
- 探索CXCL13与患者预后,免疫细胞透和三级淋巴体结构 (TLS) 的关联.
主要方法:
- 利用基因型-组织表达 (GTEx) 和癌症基因组图谱 (TCGA) 数据库用于RNA-seq数据.
- 采用基因组丰富分析和TIMER2.0用于途径和免疫细胞透分析.
- 在HNSCC样本上进行了免疫组织化学和多重光染色.
主要成果:
- 在HNSCC中,CXCL13表达被上调,并与积极的预后相关.
- CXCL13表达与B细胞和CD8+T细胞透相关,表明免疫激活.
- 观察到CXCL13,TLSs形成和有利的患者结果之间存在强烈的相关性.
- CXCL13显著增强了对癌症免疫疗法的反应.
结论:
- CXCL13作为一个潜在的预测生物标志物用于HNSCC的预后和免疫治疗反应.
- CXCL13与HNSCC瘤微环境中的TLSs的形成有关.
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