Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

From DNA to Protein03:06

From DNA to Protein

18.4K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
18.4K
Mismatch Repair01:36

Mismatch Repair

40.1K
Overview
40.1K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.9K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.9K
Genome Copying Errors02:46

Genome Copying Errors

4.2K
DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
4.2K
The Central Dogma01:25

The Central Dogma

125.8K
Overview
125.8K
DNA Base Pairing02:27

DNA Base Pairing

27.4K
Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
27.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effects of different <i>Lactobacillus plantarum</i> strains supplementation on milk performance, rumen fermentation, and microbiota in dairy cows.

Frontiers in microbiology·2026
Same author

SPI/HG composite microgels with tunable structure and rheological properties for semi-solid foods.

International journal of biological macromolecules·2026
Same author

Genetic analysis and quantitative trait loci detection of udder traits in Jersey cattle.

BMC genomics·2025
Same author

L-cysteine-mediated disulfide bond modulation enhances gelation behavior of ginkgo seed protein/hyaluronic acid gels.

Food chemistry·2025
Same author

3D-printed biodegradable soft robotic actuators using gelatin-gellan composite natural gel for sustainable and safe food automation.

International journal of biological macromolecules·2025
Same author

A dual modification approach for high-strength, and waterproof 3D printed fish gelatin-alginate tableware.

International journal of biological macromolecules·2025

相关实验视频

Updated: Jul 5, 2025

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.1K

一个对应于DNA数据存储的ASCII代码的编码表和一种新的错误纠正方法HMSA.

Xuncai Zhang, Fuzhen Zhou

    IEEE transactions on nanobioscience
    |January 22, 2024
    PubMed
    概括

    这项研究引入了一种ASCII-DNA编码方法,用于高密度的DNA数据存储,实现1.6位/nt. 一种新的错误纠正方法 (HMSA) 确保可靠的数据恢复,超过96%的准确性.

    科学领域:

    • 生物技术是生物技术.
    • 数据存储数据存储数据存储
    • 生物信息学是一种生物信息学.

    背景情况:

    • 与传统媒体相比,DNA存储提供了更好的容量,寿命和能源效率.
    • 对DNA编码的标准化对于可靠的数据表示和传输至关重要.
    • 现有的DNA数据存储方法在编码密度和错误纠正方面面临挑战.

    研究的目的:

    • 为高密度数据存储开发一个标准化的ASCII-DNA编码系统.
    • 为DNA序列提出一种新的基于启发式的错误校正方法 (HMSA).
    • 提高DNA数据存储系统的可靠性和效率.

    主要方法:

    • 将ASCII编码与DNA基结合起来,创建一个ASCII-DNA编码表.
    • 开发了一个启发式算法,集成最小的哈明距离和多次序对齐以纠错 (HMSA).
    • 编码文本,音频和视频数据,同时遵守GC内容和同聚合物约束.

    主要成果:

    • 通过绕过二进制转换,实现了1.4位/nt的编码密度,仅为文本数据增加到1.6位/nt.
    • 对于替换,插入,删除和连续的错误,HMSA方法显示出高的错误校正率 (>96%),即使在有限的测序.
    • 错误纠正效率随着测序深度的增加而提高.

    更多相关视频

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
    11:08

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

    Published on: June 19, 2018

    9.7K
    Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA
    12:35

    Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA

    Published on: November 14, 2017

    9.5K

    相关实验视频

    Last Updated: Jul 5, 2025

    Rare Event Detection Using Error-corrected DNA and RNA Sequencing
    10:36

    Rare Event Detection Using Error-corrected DNA and RNA Sequencing

    Published on: August 3, 2018

    12.1K
    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
    11:08

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

    Published on: June 19, 2018

    9.7K
    Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA
    12:35

    Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA

    Published on: November 14, 2017

    9.5K

    结论:

    • ASCII-DNA编码方法为DNA数据存储提供了标准化和高效的方法.
    • 该HMSA错误纠正方法显著提高了DNA数据恢复的可靠性,适用于各种编码方案.
    • 这项研究通过提高编码密度和错误弹性来推进DNA数据存储技术.