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心血管和认知疾病的共享蛋白质和途径:与血管认知障碍的关系

Melisa E Zeylan¹, Simge Senyuz¹, Pol Picón-Pagès²

¹Computational Sciences and Engineering, Graduate School of Science and Engineering, Koç University, Istanbul 34450, Türkiye.

Journal of proteome research

|January 22, 2024

概括

系统生物学确定了血管认知障碍 (VCI) 中的关键蛋白质和途径. 与衰老相关的氧化和糖性压力涉及VCI病变,涉及先进的糖化最终产品 (AGEs) 和RAGE信号.

科学领域:

系统生物学和计算方法的方法.
神经科学和心血管研究.
衰老和疾病的机制.

背景情况:

血管认知障碍 (VCI) 是由于血管因素导致的认知衰退,其潜在机制不明确.
衰老是主要的VCI决定因素,通常涉及氧化应激.
了解VCI需要研究心血管健康和认知功能之间的相互作用.

研究的目的:

使用系统生物学识别与VCI相关的蛋白质和途径.
在VCI中探索心血管和认知疾病之间的交叉声.
调查氧化和糖性应激在VCI病因学中的作用.

主要方法:

系统生物学和计算分析的应用.
优先考虑涉及VCI的基因和蛋白质.
在氧化应激路径中对已识别的基因/蛋白质进行丰富分析.
对糖性压力和信号通路的实验验证.

主要成果:

氧化应激途径与VCI高度相关,优先基因在这些途径中得到丰富.
确定了一份潜在的VCI贡献蛋白质清单:DOLK,TSC1,ATP1A1,MAPK14,YWHAZ,CREB3,HSPB1,PRDX6和LMNA. 这些蛋白质包括:
实验数据表明,糖化应激,高级糖化最终产品 (AGEs) 和RAGE信号对VCI有所贡献.

结论:

氧化和糖性压力是VCI的主要贡献者.
AGEs,RAGE和Notch信号与VCI的病因有关.
已识别的蛋白质为VCI研究和治疗策略提供了潜在的目标.

关键词:

心血管疾病心血管疾病认知性疾病认知性疾病交叉语音交叉语音交叉语音交叉语音交叉语音网络医学网络医学氧化应激是一种氧化应激.蛋白蛋白相互作用网络蛋白蛋白相互作用网络系统生物学系统生物学血管性认知障碍血管性认知障碍

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