细胞内在的C5a与巨细胞中的Dectin-1协同作用,以调解杀死真菌的作用
Xaria X Li1, Jenny N Fung1, Richard J Clark1
1School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, QLD 4072, Australia.
概括
补充因子C5a显著调节巨细胞中的模式识别受体 (PRR) 信号,增强对病原体的反应. 巨细胞也可以产生C5a,增强它们对抗真菌感染的防御机制.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 微生物学 微生物学
背景情况:
- 补充因子C5a (C5a) 是免疫反应的关键调解者,通过C5a受体 (C5aR1和C5aR2) 作用于髓状细胞.
- 模式识别受体 (PRRs) 检测病原体相关的分子模式,启动免疫信号.
- C5a和PRR通路之间的相互作用尚未完全理解,特别是在巨细胞中.
研究的目的:
- 调查C5a对人类巨细胞中PRR介导的细胞因子产生的调节作用.
- 探索C5a与各种PRR之间的协同相互作用,包括Dectin-1,Mincle,STING和托尔类受体 (TLR).
- 确定巨细胞是否能本质上产生C5a及其在抗真菌防御中的作用.
主要方法:
- 人类初级单细胞衍生的巨细胞被用于研究C5a-PRR相互作用.
- 对C5a对PRR介导的细胞因子反应的影响以度依赖的方式进行评估.
- 选择性Dectin-1激活被诱导使用枯竭的zymosan来调查内源C5a生产.
主要成果:
- C5a对巨细胞中PRR活动表现出强烈的双向度依赖作用.
- C5a与Dectin-1,Mincle和STING有很强的协同作用,比TLRs更强.
- 激活的Dectin-1触发了巨细胞产生C5a,从而增强了线粒体ROS生成,TNFα产生和杀死真菌.
结论:
- C5a作为一个中央免疫调节剂,显著影响巨细胞中PRR介导的反应.
- C5a通过与特定PRR的协同相互作用来增强巨细胞对病原体的防御能力.
- 巨细胞在激活Dectin-1时产生的内在C5a在宿主防御中起着至关重要的作用,特别是对抗真菌感染.
相关概念视频
01:25Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
01:40Cell-mediated Immune Responses
68.3K
Overview
68.3K
01:28Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:27Complement System
2.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.4K
01:27Cytotoxic T Cells-mediated Immune Response
921
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
921