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在基本血小板血和疾病结局中的CALR突变负担

Paola Guglielmelli1, Natasha Szuber2,3,4, Naseema Gangat5

  • 1Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Division of Hematology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

Blood
|January 22, 2024
PubMed
概括

高变异性等位基因频率 (≥60%) 在卡尔雷蒂库林 (CALR) 突变中与在没有骨髓纤维化的情况下更短的存活时间有关. 这种关联特别适用于CALR类型-1和不确定的突变.

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相关概念视频

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Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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