免疫机制是长期COVID的基础:国际医学会 (Collegium Internationale Allergologicum) 在2024年更新
Eva Untersmayr1, Carina Venter2, Peter Smith3
1Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Immunology and Infectiology, Medical University Vienna, Vienna, Austria.
International archives of allergy and immunology
|January 22, 2024
概括
长期COVID是SARS-CoV-2感染后的多系统性疾病,影响高达10%的个人. 本综述探讨了导致长期COVID的免疫因素,强调了当前治疗方法的不足以及需要机制匹配的临床试验.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 病理生理学 病理生理学
背景情况:
- 长期COVID是一种在SARS-CoV-2感染后的长期多系统性疾病.
- 它影响高达10%的个人后COVID-19.
- 不完全收回的原因尚不清楚.
研究的目的:
- 审查长期COVID病理生理学的基础上的免疫机制.
- 为了确定可能导致SARS-CoV-2感染后持续症状的潜在因素.
主要方法:
- 关于免疫机制的文献综述.
- 分析包括免疫反应,病毒储备和自身免疫力在内的因素.
主要成果:
- 潜在的机制包括不适当的免疫反应,免疫细胞疲劳和代谢重编程.
- 其他因素包括持续的SARS-CoV-2储存,病毒活性,神经炎症,自身免疫和微生物组失调.
- 饮食因素也可能起到作用.
结论:
- 目前对长期COVID的诊断和治疗选择是不够的.
- 需要更多的临床试验来使干预措施与特定的免疫机制保持一致.
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