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皮肤膏中的软化剂:为定制配方和治疗性能进行早期评估

M E Franco-Gil¹, A Graça², A Martins²

¹Research Institute for Medicines (iMed.UL), Faculty of Pharmacy, Universidade de Lisboa, Avenida Prof. Gama Pinto S/N, 1649-003 Lisboa, Portugal; Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain; University Institute of Industrial Pharmacy (IUFI), Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.

International journal of pharmaceutics

|January 22, 2024

概括

选择合适的软化剂显著影响皮肤学奶油的性能和有效性. 关键的软化特征如极性,密度和粘度会影响奶油的性能,药物释放和皮肤的感觉.

科学领域:

化品科学化品科学
皮肤病学皮肤病学
材料科学材料科学材料科学

背景情况:

软化剂是皮肤学奶油中的关键成分,决定了物理化学性质和临床疗效.
了解软化剂的影响对于优化奶油配方和治疗结果至关重要.

研究的目的:

为了研究各种软化性质对油在水皮肤学奶油特性的影响.
为了将软化剂的化学结构与奶油性能指标相关联,包括稳定性,质地和药物释放.

主要方法:

测试了7种软化剂 (,甘油三,,,植物油,矿物油) 在一个模型的油在水奶油配方.
通过使用弗朗茨细胞在六小时内评估了早期稳定性,pH值,液滴大小,风湿学,纹理 (粘性,粘性,可传播性),tribology和脂性药物释放.

主要成果:

奶油表现出酸性pH和剪切稀释,类似固体的粘弹性行为.
软化极性,密度和粘度是最有影响力的属性.
滴滴参数受到显著影响;pH和药物释放受到中度影响;纹理特性显示影响低至中度.

结论:

软化剂的选择极大地影响皮肤学奶油的配方,影响药物释放,皮肤相互作用和产品类型 (洗掉或留下).
配方优化可以通过根据所需的治疗性能,药物输送和应用需求量身定制软化剂选择来实现.

关键词:

药物释放药物释放的时间这是一种乳液乳液.配方配方配方是一个皮肤状况皮肤状况治疗上的成功.部落学 (tribology) 是一个学科.粘性弹性粘性弹性

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