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Updated: Aug 9, 2026

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
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解读分子交响曲:解开角膜内皮细胞中内皮细胞到介质细胞的转变

Zhaoxiang Lu1, Haimiao Lin2, Jinming Li2

  • 1Institute of Medical Technology, Peking University Health Science Center, Beijing, China; Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China.

Experimental eye research
|January 22, 2024
PubMed
概括

这项研究在体外模拟角膜内皮转移到介质细胞 (EndMT),识别关键基因和通路,如ECM调节和PI3K-Akt信号传递. 这些发现为角膜组织工程和细胞培养优化提供了洞察力.

关键词:
角膜内皮细胞 角膜内皮细胞最终的MT 结束的MT在RNA-Seqq.在TGF-β1中.组织工程是组织工程.

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相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...