工程双响应性原药MOFs作为免疫细胞死亡启动器,以增强癌症免疫疗法
Xiaochun Hu1,2, Ruihao Li1, Jie Liu1
1Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Department of Comprehensive Cancer Therapy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Advanced healthcare materials
|January 22, 2024
概括
这项研究引入了一种新的双响应纳米平台 (PCu-HA-DQ),该纳米平台针对瘤并增强抗癌疗法. 它有效诱导癌细胞死亡,并提高免疫检查点抑制剂的疗效.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 迪苏尔菲拉姆显示出抗癌潜力,但面临诸如铜依赖,不稳定性和癌细胞选择性差等局限性.
- 现有的纳米平台需要改进,以便在癌症治疗中提供有针对性的治疗和组合疗法.
研究的目的:
- 开发一种双响应纳米平台 (PCu-HA-DQ) 用于向癌症治疗和增强免疫检查点抑制剂 (ICI) 疗效.
- 通过创建一个专门在瘤内释放活性化合物的系统来克服dissulfiram的局限性.
主要方法:
- 通过将二硫原药 (DQ) 封装在铜金属有机框架 (PCu MOFs) 中,并用氨酸 (HA) 进行修改,构建了一个纳米平台.
- 利用CD-44受体向瘤积累和磁共振成像指导.
- 通过酸盐和过氧化触发的DQ的双反应释放被研究,导致在现场生成Cu (DTC) 2.
主要成果:
- 通过CD-44受体相互作用,PCu-HA-DQ证明了有效的瘤向和积累.
- 纳米平台成功诱导亡和免疫细胞死亡 (ICD) 在瘤细胞在体外和体内.
- 与抗编程死亡-1抗体的联合治疗显著提高了ICI疗效.
结论:
- 开发的双响应纳米平台为综合瘤向治疗和多模式治疗提供了一个有前途的战略.
- PCu-HA-DQ作为一种有效的ICD诱导剂,突出其增强全身抗瘤免疫力和ICI有效性的潜力.
相关概念视频
Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
Cytotoxic T Cells-mediated Immune Response
921
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
921
Cancer Vaccines
368
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
368
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K


