在美国使用 gabapentinoid 的最新情况, 2002-2021年
Michael E Johansen1, Donovan T Maust2,3
1Grant Family Medicine, OhioHealth, Columbus, Ohio michael.johansen@ohiohealth.com.
Annals of family medicine
|January 22, 2024
概括
成年人对 gabapentinoid 的使用量从 2015 年的 4.0% 增加到 2021 年的 4.7%,特别是在使用其他慢性疼痛药的人群中. 虽然最初的新用户数量超过了停止服用药物的用户,但这一趋势正在缩小.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- gabapentinoids 经常被处方用于各种非标签条件.
- 了解 gabapentinoid 使用趋势对于公共卫生至关重要.
- 之前的研究突出了最初的使用模式,需要更新分析.
研究的目的:
- 分析成人人口中 gabapentinoid 使用的流行率和趋势.
- 为了确定与 gabapentinoid 用户相关的人口和临床因素.
- 检查开始,停止和继续 gabapentinoid 治疗的动态.
主要方法:
- 利用了医疗支出小组调查 (MEPS) 的数据,涵盖了2002-2021年.
- 研究了成年 gabapentinoid 用户的比例和相关特征.
- 分析了新用户与随着时间的推移停止使用 gabapentinoids 的人的趋势.
主要成果:
- gabapentinoid 的使用量从 2015 年的 4.0% 增加到 2021 年的 4.7%.
- 使用其他慢性疼痛药物的个人更有可能使用 gabapentinoids.
- 慢性疼痛状况在2017-2021年期间与 gabapentinoid 使用有显著的关联.
- 在最近的队列中,新用户和停止使用 gabapentinoids 的人之间的差距缩小了.
结论:
- gabapentinoid 的使用继续增加,特别是与其他止痛药结合使用.
- 慢性疼痛状况仍然是 gabapentinoid 处方的主要驱动因素.
- 新的 gabapentinoid 启动率正在与停止率趋同,这表明长期使用模式的潜在转变.
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