在患有肥胖的参与者中,代谢状态,体力活动和心血管疾病之间的关系
Yingxin Liu1, Ai Zhao2, Guiju Sun3
1Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China.
代谢健康的肥胖 (MHO) 和体育活动 (PA) 独立地降低肥胖成人心血管疾病 (CVD) 风险. 此外,PA还修改了代谢状态和心血管疾病风险之间的联系,强调了其重要性.
科学领域:
- 心血管疾病流行病学
- 肥胖和代谢健康问题
- 身体活动和健康结果.
背景情况:
- 肥胖是心血管疾病 (CVD) 的重要危险因素.
- 代谢状态和体力活动 (PA) 是影响肥胖个体健康的关键因素.
- 了解代谢健康,PA和心血管疾病风险之间的相互作用对于有针对性的干预至关重要.
研究的目的:
- 研究代谢状态和体力活动 (PA) 对心血管疾病 (CVD) 风险的独立和联合影响.
- 检查身体活动如何改变代谢健康肥胖 (MHO) 和代谢不健康肥胖 (MUO) 与心血管疾病风险之间的关联.
主要方法:
- 一项对109,301名肥胖成人进行的队列研究,没有基线心血管疾病,来自英国生物银行.
- 参与者被分为代谢健康肥胖 (MHO) 和代谢不健康肥胖 (MUO) 组.
- 身体活动 (PA) 分类为没有,低,中和高水平的中度至强烈的PA (MVPA);用于分析的Cox回归模型.
主要成果:
- 与代谢不健康的肥胖 (MUO) 相比,代谢健康的肥胖 (MHO) 与心血管疾病风险降低42%有关.
- 身体活动 (PA) 在MUO患者中显著降低了心血管疾病风险.
- 在中等PA水平的MHO组中,与没有PA的MUO相比,观察到的CVD风险最低.
结论:
- 无论是MHO还是任何水平的中度至强度PA (MVPA),都与肥胖成年人心血管疾病风险降低有关.
- 身体活动 (PA) 在改变肥胖个体的代谢状态和心血管疾病风险之间的关系方面发挥着至关重要的作用.
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