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Updated: Jul 5, 2025

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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lysosomal 功能障碍的先天免疫感知驱动多个 lysosomal 存储障碍

Ailian Wang1,2,3, Chen Chen1, Chen Mei1,2,3

  • 1MOE Laboratory of Biosystems Homeostasis and Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Nature cell biology
|January 22, 2024
PubMed
概括

溶酶体储存障碍 (LSD) 触发神经元内在的cGAS-STING信号,导致细胞死亡. 针对这种途径为各种LSD提供了统一的治疗策略.

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