与妇科癌症相关的甲状腺功能低下症和甲状腺功能过高症:全国范围的基于人口的队列研究
John Hang Leung1, Shyh-Yau Wang2, Henry W C Leung3
1Department of Obstetrics and Gynecology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Road, East Dist., Chiayi, 60002, Taiwan.
Scientific reports
|January 22, 2024
概括
患有甲状腺功能障碍的女性面临患妇科癌症的风险降低,而甲状腺功能障碍症与稍微增加的风险有关. 这项研究强调了甲状腺功能与妇科癌症发展之间的联系.
科学领域:
- 内分泌学 在内分泌学.
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
背景情况:
- 甲状腺功能障碍,包括甲状腺功能过高和甲状腺功能低下,影响全球众多女性.
- 甲状腺疾病与患妇科癌症的风险之间的关系尚不完全理解.
- 了解这些关联对于全面的妇女健康管理至关重要.
研究的目的:
- 调查甲状腺功能障碍症和甲状腺功能障碍症之间的关联以及患上特定妇科癌症的风险.
- 量化甲状腺功能障碍的妇女患子宫内膜,子宫体和卵巢癌的风险.
- 探索这些协会中潜在的与年龄相关的差异.
主要方法:
- 使用台湾国家健康保险研究数据库 (2000-2018) 进行了基于人口的回顾性队列研究.
- 这项研究包括被诊断患有甲状腺功能障碍,甲状腺功能障碍和控制组的妇女.
- 考克斯的比例危险模型被用来计算妇科癌症的发病率和调整的危险比率 (aHR).
主要成果:
- 患有甲状腺功能障碍的女性患妇科癌症的发病率显著降低 (aHR=0.86).
- 患有甲状腺功能低下症的女性的妇科癌症发病率略有增加 (aHR=1.13).
- 年龄较大的年龄组 (40-65岁和65岁以上) 在甲状腺功能过高和甲状腺功能下降的个体中表现出不同的风险变化.
结论:
- 甲状腺功能障碍与妇科癌症风险降低有关.
- 甲状腺功能低下症显示出妇科癌症的风险略高.
- 甲状腺功能状况似乎在妇科恶性瘤的风险概况中起作用.
相关概念视频
01:24Disorders of the Female Reproductive System
364
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
364
01:23The Thyroid Gland
3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
01:30Hormonal Control of the Ovarian Cycle
518
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
518
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K