通过调节RAGE/JAK2/STAT3信号通路,S100A8/A9促进子宫内膜纤维化
Xing Xin1,2, Hao Liu3,4,5, Siwen Zhang1,2
1Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, 110022, Shenyang, China.
Communications biology
|January 22, 2024
概括
子宫内粘附 (IUA) 涉及子宫内膜纤维化. 增加的S100A8 / A9蛋白通过特定的途径驱动这种纤维化,但月经血液衍生的树皮细胞 (MenSCs) 在恢复子宫组织方面显示出治疗潜力.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 纤维化研究 纤维化研究
背景情况:
- 子宫内粘附 (IUA) 是一种由子宫内膜纤维化标志的疾病.
- 已知S100A8/A9会影响炎症和纤维细胞活动,但其在IUA中的具体作用尚不清楚.
研究的目的:
- 为了研究S100A8/A9在IUA病变发生中的作用.
- 探索月经血液衍生性树皮细胞 (MenSCs) 作为IUA的治疗剂的潜力.
主要方法:
- 在正常和IUA子宫内膜中分析S100A8 / A9表达.
- 在体外研究中,使用用S100A8/A9.9治疗的人类子宫内膜层细胞 (hEnSCs) 进行了S100A8/A9.
- 建立IUA的猪模型来评估MenSC移植.
主要成果:
- 在IUA子宫内膜内,S100A8/A9表达升高.
- 通过RAGE-JAK2-STAT3通路,S100A8/A9促进hEnSCs的增殖,并通过RAGE-JAK2-STAT3通路调节纤维化和炎症标志物.
- 在猪IUA模型中进行MenSC移植改善了血管生成,减少了纤维化,并降低了S100A8 / A9水平.
结论:
- 通过RAGE-JAK2-STAT3信号通路,S100A8/A9有助于IUA中的子宫内膜纤维化.
- 在临床前IUA模型中,MenSCs在子宫内膜修复方面表现出显著的治疗疗效.
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