一个自动化的深度学习管道用于EMVI分类和使用基线MRI预测直肠癌的反应:一个多中心研究
Lishan Cai1,2, Doenja M J Lambregts1,2, Geerard L Beets2,3
1Department of Radiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
NPJ precision oncology
|January 22, 2024
概括
一个新的自动化深度学习管道准确地分类外壁血管侵袭 (EMVI),并预测使用MRI的直肠癌患者的完整反应 (CR). 这种方法表现出强烈的概括性,优于现有模型,可以更好地规划治疗.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 人工智能的人工智能
背景情况:
- 外围血管侵袭 (EMVI) 是直肠癌的关键预后标志物,预测完整反应 (CR) 有助于治疗决策.
- 目前用于EMVI分类和CR预测的放射学方法通常需要手工细分和手工制作的特征,这限制了它们的通用性.
研究的目的:
- 开发和验证一个完全自动化的深度学习管道,用于EMVI状态分类和CR预测,使用初级分期MRI.
- 与现有方法相比,提高EMVI分类和CR预测的准确性和通用性.
主要方法:
- 分析了来自9个中心的509名直肠癌患者的回顾性队列.
- 开发了使用nnUNet进行瘤细分的全自动化管道,以及采用扩散权重成像 (DWI) 和T2权重成像 (T2WI) 的多层次图像特征的新型深度学习模型 (MLNet).
- MLNet接受了EMVI分类和CR预测的培训,在内部和外部验证集上评估了性能.
主要成果:
- 在EMVI分类和CR预测的内部和外部验证数据集上,MLNet取得了强的表现.
- 在外部验证方面,MLNet在两个任务中都超过了3D ResNet10模型.
- 对于CR预测,MLNet超越了当前最先进的模型,该模型在同一外部队列中使用了成像和临床特征.
结论:
- 拟议的自动化深度学习管道,结合多层次图像表示,显著提高EMVI分类和CR预测准确性和概括性.
- 这种方法具有临床应用的潜力,特别是提高直肠癌分期的EMVI分类.
更多相关视频
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
8.3K
07:15Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
Published on: August 16, 2020
6.8K
相关概念视频
01:24Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
01:21Imaging Studies for Cardiovascular System IV: CMRI
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
01:27Imaging Studies IV: Magnetic Resonance Imaging
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...