来自不同来源的饮食维生素A摄入量与成年人非酒精性脂肪肝疾病之间的关联
Can Liu1,2, Xiaona Sun3, Jing Peng4
1School of Public Health, Shanxi Medical University, Taiyuan, China.
Scientific reports
|January 22, 2024
概括
饮食中提供维生素A类胡卜素的摄入可能会降低非酒精性脂肪肝疾病 (NAFLD) 的风险. 这种反向关联在女性和年轻人中特别被注意到,这表明它起着保护作用.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题,患病率数据各不相同.
- 食维生素A对NAFLD风险的具体影响需要进一步研究.
研究的目的:
- 检查来自各种来源的食维生素A与美国成年人中NAFLD风险之间的关联.
- 为了澄清总维生素A,预制维生素A和前维生素A类胡卜素摄入量与NAFLD之间的关系.
主要方法:
- 利用了2007-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 采用后勤回归和受限立方线模型进行分析.
- 包括6613名成年参与者,调整了潜在的混因素.
主要成果:
- 较高摄入的维生素A类胡卜素显示与NAFLD风险的反向关联 (OR:0.78;95%CI:0.61-0.99).
- 这种反向关系在女性和45岁以下的成年人中更为明显.
- 在前维生素A类胡卜素和NAFLD风险之间观察到线性负剂量反应关系.
结论:
- 饮食中提供维生素A类胡卜素的摄入与美国成年人中NAFLD风险相反相关.
- 保护作用在女性和年轻人 (<45岁) 中尤为显著.
- 进一步研究维生素A在NAFLD病原体中的作用是有必要的.
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