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2型糖尿病中心血管疾病的精确预后:系统性审查和元分析
Abrar Ahmad1, Lee-Ling Lim2,3,4, Mario Luca Morieri5,6
1Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Communications medicine
|January 22, 2024
概括
新型生物标志物如NT-proBNP和Troponin-T显示出改善心血管疾病 (CVD) 风险预测在2型糖尿病 (T2D) 的前景. 需要进一步的研究来证实它们在管理T2D患者心血管疾病风险方面的临床实用性.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 精准医学是一门精准的医学.
背景情况:
- 精准医学在2型糖尿病 (T2D) 患者中提供了增强心血管疾病 (CVD) 风险预测的潜力.
- 目前的风险预测模型可能无法完全捕捉T2D人群中的个人心血管疾病风险.
研究的目的:
- 系统地审查和元分析纵向研究.
- 确定可以改善T2D中心血管疾病风险预测的新型预后因素.
- 评估各种生物标志物,遗传标志物和风险评分的预测效用.
主要方法:
- 416项纵向研究的系统综述和元分析.
- 纳入标准适用于9380个确定的研究.
- 分析了321个生物标志物,48个遗传标志物和47个风险评分/模型研究的结果.
主要成果:
- N-终端pro b型尿素 (NT-proBNP) 显示出高预测效用 (高证据).
- 热波-T (TnT),甘油三-葡萄糖 (TyG) 指数和冠状动脉心脏病 (GRS-CHD) 遗传风险评分显示了中等的预测效用 (中等证据).
- 其他标记物,如C反应蛋白和冠状动脉分数,具有较低的预测效用.
结论:
- 很少有研究严格评估了T2D中已确定的心血管疾病风险因素之外的增量预测效用.
- NT-proBNP,TnT,TyG指数和GRS-CHD是T2D中CVD风险分层的有希望的标志物.
- 进一步的研究对于确定这些标记物在T2D患者心血管疾病管理中的临床实用性至关重要.
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