新型预后诺莫图谱用于预测甲状腺髓性癌的无复发生存率
Yagiz A Aksoy1,2,3, Bin Xu4, Kartik Viswanathan5
1Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia.
Histopathology
|January 22, 2024
概括
一个新的预后性诺图谱准确地预测了状甲状腺癌 (MTC) 患者的无复发生存期 (RFS). 这种基于临床病理学因素的工具有助于指导切除MTC的治疗决策.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 手术病理学手术病理学
背景情况:
- 准确的预后对于指导甲状腺髓癌 (MTC) 治疗至关重要.
- 国际MTC分级系统 (IMTCGS) 于2022年建立,以改善MTC预后.
- 需要有效的工具来预测MTC患者的无复发生存期 (RFS).
研究的目的:
- 开发和验证用于预测切除MTC的患者的RFS的预后性名录.
- 通过创建更精确的预测模型,利用IMTCGS的发现.
- 提供一个工具,帮助临床医生在MTC患者管理决策.
主要方法:
- 使用来自五个国际中心300名MTC患者的数据开发了一个多变量预测模型.
- 包括关键的临床病理变量,包括年龄,性别,AJCC阶段,瘤大小,线粒细胞计数,缩,Ki67指数,淋巴血管入侵,甲状腺外延伸和边缘状态.
- 该模型的性能通过10倍交叉验证进行了优化,并在87名MTC患者的单独队列上进行了外部验证.
主要成果:
- 开发的名图表显示出强大的预测性能,曲线下的面积 (AUC) 为0.94,一致性指数 (C指数) 为0.876.
- 外部验证证实了模型的稳定性,达到0.9.9的AUC.
- 该模型有效预测了切除的甲状腺髓癌患者的无复发生存期 (RFS).
结论:
- 已经开发了一个强大的,外部验证的多变量预测模型,用于切除MTC中的RFS.
- 诺米图表表现出卓越的预测能力,可以帮助MTC患者管理的临床决策.
- 预后诺莫图可在网上查看,用于临床使用.
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